Publications — Pernas Lab

Research

Mitochondria shed their outer membrane in response to infection-induced stress.
Li, X., Straub, J., Medeiros, T., Mehra, C., den Brave, F., Peker, E., Atanassov, I., Stillger, K., Michaelis, J.B., Burbridge, E., Burbridge, E., Adrain, C., Münch, C., Riemer, J., Becker, T., and Pernas, L. (2022) Science
selected for preview:
Molting Mitochondria Ulrich, F. (2022) Nat Struct Mol Biol.;
Hijacking of host mitochondria by Toxoplasma gondii and SARS-CoV-2 Zhang, R. et al., (2022) Trends Parasitol.
SPOTting stress at the mitochondrial outer membrane Schuler, M. and Hughes, A.L. (2022) Mol Cell
Hunger games in the host cell: Toxoplasma traps & skins host mitochondria Hakimi, M.A. (2022) Cell Host Microbe

The mitochondrial protein OPA1 promotes adipocyte browning that is dependent on urea cycle metabolites.
Bean, C., Audano, M., Varanita, T., Favaretto, F., Medaglia, M., Gerdol, M., Pernas, L., Stasi, F., Giacomello, M., Herkenne, S., Muniandy, M., Cazaly, E., Ollikainen, M., Milan, G., Pallavicini, A., Pietilainen, K., Vettor, M., Scorrano, L. (2021) Nat Metabolism

Mitofusin 1 is required for the oocyte-granulosa cell communication that regulates oogenesis.
Machado TS*, Carvalho DF*, Garcia BM*, Zangirolamo AF, Macabelli CH, Sugiyama FHC, Grejo MP, Neto JDA, Ribeiro FKS, Sarapião FD, Meirelle FV, Guimarães FEG, Pernas L, Seneda MM, Chiaratti MR. (2020) FASEB J.

Mitochondria restrict growth of the intracellular parasite Toxoplasma by limiting its uptake of fatty acids. Pernas, L., Bean, C., Boothroyd, J.C., and Scorrano, L. (2018) Cell Metabolism
selected for preview:
Fighting for Resources: Who Started the Battle? Who Is Winning It?
Zuzarte-Luis, V. and Mota M.M. (2018) Cell Metabolism
editor’s choice (2018) Science, Hurtley, S

A Toxoplasma gondii locus required for the direct manipulation of host mitochondria has maintained multiple ancestral functions. Blank, M.L., Parker, M.L., Ramaswamy, R., Powell, C.J., English, E.D., Adomako-Ankomay, Y., Pernas, L., Workman, S.D., Boothroyd, J.C., Boulanger, M.J., and Boyle, J.P. (2018) Molecular Microbiology

Gene duplication-driven evolution of a novel trait in Toxoplasma gondii and its near relatives. Adomako-Ankomah, Y., English, E.D., Danielson, J.J., Pernas, L., and Boyle, J.P. (2016) PLoS Genetics

Toxoplasma effector MAF1 mediates recruitment of host mitochondria and impacts the host response.
Pernas, L., Adomako-Ankomah, Y., Shastri, A.J., Ewald, S.E., Treeck M, Boyle, J.P., and Boothroyd, J.C. (2014) PLoS Biology
Selected for synopsis:
MAF1 sequesters mitochondria for Toxoplasma gondii. Sedwick, C (2014) PLoS Biology, F1000 Prime Article

Metabolic immunity against microbes
Kreimendahl, S. and Pernas, L. (2023) Trends in Cell Biology

Contact and competition between mitochondria and microbes
Medeiros, T.C., Mehra, C., and Pernas, L. (2021) Current Opinion in Microbiology (PDF)

RevAMPing Mitochondrial Shape to Live Longer. Pernas, L. and Scorrano, L. (2017) Cell Metabolism