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      <image:caption>Host cells weaponize mitochondrial metabolism: upon detection of secreted parasite effectors, host cells activate the ISR. The ISR effector ATF4 increases mtDNA levels and induces mitochondrial one-carbon (mito-1C) metabolism, thereby restricting Toxoplasma access to the folate(s) that it requires for dTMP synthesis and growth.</image:caption>
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      <image:caption>Mitochondria shed SPOTs during Toxoplasma infection. (Left) Mitochondria surrounding the parasite Toxoplasma (red) shed SPOTs, large structures positive for OMM (yellow) that lack mitochondrial matrix (cyan). (Right) Cartoon depiction of image at left as infection progresses (clock). OMM proteins—including the import translocase SAM50, and MFN1 and MFN2, which are required for mitochondrial fusion—are sequestered on SPOTs.</image:caption>
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      <image:caption>Impaired folliculogenesis in Mfn1-deficient oocytes is associated with abnormal mitochondrial architecture and function.</image:caption>
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      <image:caption>Pulsed fluorescent fatty acids (FAs) remain largely in lipid droplets in uninfected cells but increasingly accumulate in mitochondria (indicated by white arrowheads) at early stages of Toxoplasma infection (parasite vacuoles indicated by dashed lines).</image:caption>
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      <image:caption>Host mitochondria (red) surrounding Toxoplasma (green)</image:caption>
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      <image:caption>Uninfected (left) and Toxoplasma-infected (right) adipocytes. Parasite vacuoles are pseudocolored red, scale bar 5um. N-nucleus, LD-lipid droplet.</image:caption>
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